Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo
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چکیده
منابع مشابه
Regulation of Diacylglycerol Kinase by Phosphoinositide 3-Kinase Lipid Products*
Diacylglycerol kinase (DAGK ), like all type I DAGKs, has calcium regulatory motifs that act as negative regulators of enzyme activity and localization. Accordingly, DAGK is activated by phospholipase C-coupled receptors in a calcium-dependent manner. One of the first functions attributed to DAGK in lymphocytes was that of regulating interleukin 2-induced cell cycle entry. Interleukin-2 nonethe...
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Synapses are specialized communication points between neurons, and their number is a major determinant of cognitive abilities. These dynamic structures undergo developmental- and activity-dependent changes. During brain aging and certain diseases, synapses are gradually lost, causing mental decline. It is, thus, critical to identify the molecular mechanisms controlling synapse number. We show h...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2004
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.24.3.966-975.2004